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Maybe things just arent working like they used

While timing alone is unlikely to be the sole cause, it is one piece of the optimization puzzle that is easy to adjust and test

More significant results typically occur over several months with consistent treatment and healthy lifestyle habits

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However, in contrast to the indirect mechanism underlying indole-evoked activation of the vagus nerve, submucosal neurons in hemisected tissue preparations were not activated by indole either, although we acknowledge that carrying out these studies at room temperature may have had an impact on temperature-sensitive elements