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Most patients are diagnosed in the early weeks of treatment and have no symptoms or only mild signs

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When administered as a subcutaneous injection, Semaglutide activates GLP-1 receptors in the brain, promoting feelings of fullness and reducing hunger

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A potentially more clinically realistic analysis testing the impact of continuing oral semaglutide and liraglutide alongside basal insulin therapy before intensification to basal-bolus insulin was also explored, and this showed further benefits in clinical outcomes and cost-effectiveness were possible with oral semaglutide (Table 3 and Fig