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& Copani, A

It also plays a role in reducing melanin production by interfering with tyrosinase, the enzyme responsible for melanin synthesis

This is the most stable state for peptides, as it helps them maintain their integrity and potency for a long time

More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]

This tripeptide is ubiquitous in nature and is produced by every organism from bacteria, to plants to animals that derives energy from oxidative phosphorylation and respiration