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These post-translational changes disrupt enzymatic function, alter proteinprotein interactions, and compromise proteostasis
In some embodiments, the otic formulation or composition comprises about 0.2% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof
Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism
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Chemical Stability of Insulin, 1: Hydrolytic Degradation During Storage of Pharmaceutical Preparations
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