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NHS access requires BMI 35 kg/m with weight-related comorbidities, specialist referral, and prior engagement with lifestyle interventions

Common early side effects noted in the FAQ include nausea or fatigue, which the company describes as typically improving as the body adapts

Here, we systematically reviewed existing scientific literature using keywords selected by authors that might be considered a limitation of the study

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this effect seems to be due to different mechanisms, including reduced expression of proinflammatory mediators such as TNF, IL-6, and p-NFkB, attenuation of endoplasmic reticulum stress, reduction in hepatocyte apoptosis, decreased accumulation of fibronectin and alpha-smooth muscle actin (-SMA), and reduction in plasminogen activator inhibitor 1 (PAI-1) expression [87, 88]