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Strong evidence supports FDA-approved indications where applicable

The pain radiated from the outside of my elbow down into my forearm, and gripping anything became a real chore

For example, in a new study, patients who first used a daily topical treatment gel containing 0.1% adapalene and 2.5% benzoyl peroxide for 2-4 weeks before undergoing 3 treatments with Sebacia, spaced 1-2 weeks apart, saw an improvement of 66% at 3 months, as compared to those who had Sebacia alone (in the clinical trials), and showed 49% improvement at 3 months

The reasoning is that oral bioavailability is ~4050%, and animal study HED conversions suggest higher doses may be needed for the full effect

Others do well on a monthly schedule