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By gene profiling of aorta samples and evaluation of anti-inflammatory properties of semaglutide in an acute in vivo inflammation model Rakipovski G, et al

The primary outcome was a composite measure that included psychiatric hospitalizations, extended sick leave for psychiatric reasons, hospitalization due to self-harm, or death by suicide

However, several drugs have been approved and clinically implemented for obesity caused by other genetic mutations in the MC4R pathway, as summarized in Table 4