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Additionally, in MDD, aberrant DNA methylation at stress-related loci, including the glucocorticoid receptor gene NR3C1 and FKBP5 and neurotrophic genes (such as BDNF ) are well documented 9
All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)
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The peptides effects on blood vessel formation merit consideration as well
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