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A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal

Plant and Cell Physiology 51, 2010

The energy boost from B12 is often the first noticeable change, with many patients reporting improved alertness and reduced fatigue within the first few days after their initial injection