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8).3,8,9,51 Other criteria suggestive of melanoma are the presence of multinucleation and a significant increase in melanocytic density (in contrast to subungual lentigo, where the increase is only moderate).33,51 Lentiginous spread of melanocytes towards the eponychium or hyponychium may constitute, when present, another useful key to diagnosis of subungual melanoma, as it is an indication of the capacity for invasion of surrounding structures.3,72 Subungual melanoma

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