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Adults 18-65 show robust weight loss (15-22% body weight) in clinical trials, while older adults (65+) demonstrate similar relative benefit but may experience different gastrointestinal tolerability profiles

Wegovy was designed and studied for continued use at therapeutic doses typically 1.7 mg or 2.4 mg weekly, and now up to 7.2 mg weekly under the Wegovy HD approval (March 2026)

Classification of EdU+ cells as RGL-NSCs, IPCs or neither revealed that this reduction in EdU labeling was driven primarily by loss of EdU+ IPCs (Fig