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While further study is needed to explicitly link semaglutide to lipedema treatment outcomes, its ability to reduce general body weight and improve insulin sensitivity makes it an appealing alternative for symptom management

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It undergoes enzymatic processing from its preproglucagon peptide precursor within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and peptide variants including GLP-1(7-36)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Peake J, Suzuki K