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Combining the over-expression of endogenous or exogenous -GCS and GS can effectively increase GSH synthesis [6]

Glucose homeostasis is achieved by tight regulation of insulin secretion from pancreatic cells in response to various physiological factors, including nutrients and hormonal and neuronal inputs

The enzymes utilized in this pathway mediate a set of reversible reactions that lead to the production of ribose-5-phosphate, xylulose-5-phosphate, sedoheptulose 7-phosphate, and erythrose 4-phosphate, as well as intermediates utilized in the glycolytic pathway, including glyceraldehyde-3-phosphate and fructose-6-phosphate