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The EU requires this ingredient to be listed separately on an ingredients list

Biochemical pharmacology 86 , 200209, doi: 10.1016/j.bcp.2013.05.007 (2013)

DSIP was first isolated in 1977 from the cerebral venous blood of rabbits during induced sleep by a Swiss research group

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Seventy percent of study volunteers showed collagen increases compared to untreated controls a response rate significantly higher than that achieved by either comparator compound, both of which are considered first-line clinical options for photoaged skin