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These simulations utilized the lowest-energy solution of the NMR-derived ensemble of the p53 TAD2 -FOXO4-DRI complexes as our starting geometry (see methods)
With advancements in HRW preparation methods, such as water electrolysis (Santos et al., 2017), metal-acid reactions (Xie et al., 2020), and high-pressure dissolution, an increasing number of clinical trials have begun to adopt the consumption of hydrogen-rich water as a means of hydrogen intake for the treatment of neurological disorders
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For the in vitro experiments, silencing CA9 abrogated ATT-I-mediated Claudin-1, Occludin, GPX4 and SLC7A11 upregulation in Erastin-treated Caco-2 cells, indicating that CA9 is an indispensable mediator for ATT-I to restrain Erastin-induced ferroptosis in Caco-2 cells
Creatine monohydrate is the most widely available form of creatine
