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Direct evidence to support cellmediated GLP-1 secretion as the mechanism of FATP2-KOassociated hyperinsulinemia included (a) colocalization of FATP2 with human and mouse islet , but not , cells, (b) FATP2 mRNA expression in human and mouse , but not , cells, (c) inhibition of fatty acid uptake by FATP2 inhibitors in cells, (d) increased GLP-1 + cell mass in FATP2-KO db/db mice, (e) an increased Pcsk1 / Pcsk2 mRNA ratio in TC1-6 cells treated with lipofermata, and (f) enhanced GLP-1 secretion and exendin[9-39]inhibitable GSIS in FATP2 inhibitortreated human islets

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GLP-1 is a hormone of the gastrointestinal tract which is stimulated upon consumption of food