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The prevalence has been reported to range from 0.4% in an unselected healthy adult population in Japan to 5% among clients at a family planning clinic.1 The rate is even higher among patients with specific symptoms that may be attributable to hyperprolactinemia: it is estimated at 9% among women with amenorrhea, 25% among women with galactorrhea and as high as 70% among women with amenorrhea and galactorrhea.1 The prevalence is about 5% among men who present with impotence or infertility.1 Regulation of prolactin secretion Like most anterior pituitary hormones, prolactin is under dual regulation by hypothalamic hormones delivered through the hypothalamicpituitary portal circulation (Fig

In the clinical trials of retatrutide, dose escalation was paused or reduced when participants experienced intolerable side effects, most commonly gastrointestinal symptoms such as nausea, vomiting, or diarrhoea

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