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Notably, during models CASSCF(14, 13) geometric optimization, the HOMO and LUMO molecular orbitals drew our attention from the beginning (Figs S1-S3, in Supporting Information (SI))

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In ErbB2-transformed MCF10A cells, there is increased expression of GLS mRNA and protein compared to MCF-10A cells, and knockdown of ErbB2 leads to downregulation of GLS expression [103]