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Further, optimization can be achieved by including certain lifestyle or dietary changes as recommend in EAU guidelines, to prevent the deterioration requiring medical or surgical treatment [9]

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Moreover, there was a slight disruption of the hepatocytes and a higher infiltration of inflammatory cells in the conjunctive tissue around the portal space (see arrows on image D)

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However, despite the initial high hopes and decades of compelling findings, interest in these molecular chaperones has markedly declined over the past decade