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Shin splints develop when repetitive stress causes tiny tears or inflammation in the muscles and connective tissue surrounding the tibia

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One compelling histopathological correlate of disability progression is the slowly-expanding lesion, characterized by a presumably inactive gliotic demyelinated center surrounded by a rim of activated microglia and macrophages containing degenerated myelin, injured axons and often iron deposition (Dal-Bianco et al., 2017