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The substantial impact of LASSS pre-treatment was more pronouncedly demonstrated by an alternative experiment using the disulfide lipoic acid (LA, containing two sulfur atoms connected by a disulfide bond)

Systemic administration also worked, but local delivery produced the strongest results consistently

doi: 10.1158/1078-0432.CCR-04-2159

Thus, we propose that these structural rearrangements are due to the positioning of the hydrogen bond, which could affect the flexibility of nearby loops, and possibly trigger the movement of the Cys190-containing loop ( Figure 7D )

How Liposomal Glutathione Helps Protects intestinal cells from oxidative damage