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The core consists of dead neural tissue, while the penumbra has a metabolically compromised yet salvageable area that serves as the primary target for neuroprotective interventions [20]

Management strategies: Ensure adequate caloric intake (extreme restriction worsens fatigue) Prioritize sleep (7-9 hours) Maintain light exercise (walking, stretching) Check hydration and electrolyte levels B-vitamin supplementation may help some people Detailed guides on fatigue include GLP-1 fatigue , semaglutide fatigue , and does tirzepatide make you tired