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Glutathione monoethyl ester: uptake by tissues and conversion to glutathione
In further studies, only the formation of [14C]carbon dioxide from [14C-1]glucose was measured, with the addition of: sodium ascorbate (which undergoes a non-enzymic reaction in air to produce hydrogen peroxide) acetylphenylhydrazine (which is known to precipitate haemolysis in sensitive subjects, and depletes glutathione) methylene blue (which oxidises NADPH) All incubations were repeated in the presence and absence of N -ethylmaleimide, which undergoes a non-enzymic reaction with the -SH group of reduced glutathione, and thus depletes the cell of glutathione
At 180 days follow-up, death (HR 1.10, 95% CI 0.572.14) and heart failure rehospitalization (HR 1.30, 95% CI 0.891.88) did not differ compared with those in the placebo group
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160,161,162 MCU stimulates PDAC cell invasion, migration, and metastasis via activating the Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 antioxidant pathway
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