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As a dual agonist, tirzepatide (GLP-1 + GIP) continues to outperform semaglutide in weight loss and metabolic control, setting a new bar for combination therapies

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doi: 10.1016/j.jpeds.2021.05.009

Important limitations on this safety profile: the longest trial was 24 weeks, the total trial population is small by modern standards, and the clinical trials used oral dosing

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