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When you make the retina more hypoxic, which is what the GLP-1s do, it basically pushes it further over the threshold, causing more abnormal blood vessels to grow, said Linda Lam, MD, MBA, an ophthalmologist with Keck Medicine of USC, who wasnt involved in the research

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The Stanford Medicine clinicians we spoke with pushed back on that framing

Women make up 63% of our overall cohort (even higher for weight-loss) and show incredible health improvements lower incidence of key cancers and significant cardiovascular event reductions

This faster escalation reflects retatrutides triple-agonist mechanism: the glucagon receptor component may improve tolerability at higher incretin doses by providing additional metabolic pathways for the body to utilize the compound