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The physiological rationale for the sleep finding is that GH is secreted preferentially during slow-wave sleep, and the ghrelin system has independent links to sleep architecture, so a ghrelin-receptor agonist plausibly modifies both

If not tolerated, temporarily decrease to 1.7 mg once weekly for a maximum of 4 weeks, then increase back to 2.4 mg once weekly

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(41), who investigated gene expression profiles of human leukocytes at 2, 4, 6, 9, and 24 hours following endotoxin infusion

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