These include alterations in MEC II pyramidal cell projections to the hippocampal CA1 and cortical areas, as well as stellate cells targeting the dentate gyrus and CA3 regions, both of which are involved in memory and spatial navigation (Krishnan et al., 2025)
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The aggregation is due to the folding of the amyloids in a way that causes similar nearby ones to fold in a similar way a process akin to the propagation of prion amyloids in mad-cow disease and in its human counterpart, Creutzfeldt-Jakob disease (Goedert, 2015
Here we take a closer look at amino acid properties, how they are used in the body and where they come from
