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such difference could explain the absence of rKOR phosphorylation when activated by U50,488 (Li et al., 2002)

In the connection between mitochondrial metabolism and aging, prior work reported decreased levels of LAC in subjects with Alzheimers disease (AD) as compared to cognitively healthy controls, with intermediate levels in subjects with subjective memory complaint or mild cognitive impairment [64]

In the context of cell death, ROS are key mediators of apoptosis, necrosis, and ferroptosis, with their levels determining cell survival or death [214, 549]

The two routes therefore come out broadly comparable once the goal is factored in

10.1042/BJ20101884 Biochem