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Pregnant or breastfeeding women are typically advised against use due to insufficient research

Each appointment, even for a quick injection, requires a nurses time, a consultation room, and administrative handling

BPC-157s modulation of pro-inflammatory cytokines, without suppressing normal immune function the way corticosteroids do, makes it a useful tool for patients who need repeated joint management but want to avoid the tissue-degrading effects of repeated cortisone injections