However, promising trial results do not mean the drug is available for public use
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and GLP-1/GIP dual agonists, collectively referred to as GLP-1-based medications, have transformed the treatment landscape for obesity and cardiometabolic disease
Semaglutide and tirzepatide have their marketing authorizations, but neither is reimbursed in France for obesity as of May 2026, despite favorable opinions from the French National Authority for Health (HAS)
A recombinant human glucagon-like peptide (GLP)-1-albumin protein (Albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
Tapering versus abrupt cessation The clinical trials did not specifically study tapering protocols, but physiological principles suggest a gradual dose reduction may produce a smoother transition than abrupt cessation