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When butyrate was administered directly to intestinal epithelial stem cells, which are located at the base of the crypts and are anatomically shielded from exposure to SCFAs, it inhibited HDAC activity and increased H3K9 and K27 acetylation, which was accompanied by decreased proliferation and a diminished ability to respond to injury [147, 148]

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The balance between spermatogonial stem cell self-renewal and differentiation in the adult testis grants cyclic waves of spermatogenesis and potential fertility