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Strong arguments in favor of PS exposure being required for microvesicle release come from (1) a bleeding disorder, the Scott syndrome, where RBC neither translocate PS across the membrane nor release microvesicles (Bevers et al., 1992) and (2) the finding that a specific inhibitor of the scramblase (R5421) inhibits both PS exposure and microvesicle release to more than 50% (Gonzalez et al., 2009)

Pharmacodynamic and efficacy analysis of the BRAF inhibitor dabrafenib (GSK436) in combination with the MEK inhibitor trametinib (GSK212) in patients with BRAFV600 mutant colorectal cancer (CRC)

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