The second receptor target is GIP (glucose-dependent insulinotropic polypeptide), which works synergistically with GLP-1 to enhance insulin sensitivity and further regulate appetite
Retatrutide is currently under investigation across six therapeutic research areas: obesity, type 2 diabetes, knee osteoarthritis, obstructive sleep apnoea, chronic low back pain, and metabolic dysfunction-associated steatotic liver disease, a breadth of scientific application that drives multi-protocol demand across research institutions worldwide
Nature, 2024, doi:10.1038/s41586-024-07419-8
Found 12% of US adults currently taking a GLP-1 drug (up from 6% in May 2024)
To complicate matters, microdosing programs typically rely on compounded versions of the medication, which carry their own risks