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First few months: This is typically the active titration phase - providers adjusting the dose based on tolerance and response, GI side effects (when present) often diminishing, and more visible weight changes becoming apparent for patients who respond to treatment

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261265 Therefore, by inducing pro-inflammatory adhesion molecules and chemokines, hypoxia causes the accumulation of macrophages in the kidney that produce profibrotic cytokines such as transforming growth factor and activate renal fibrobalsts