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A glimpse of various pathogenetic mechanisms of diabetic nephropathy

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Abstract Background The potential benefits and risks of combination therapy with sodium-glucose co-transporter-2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) versus monotherapy remain a subject of debate to optimize metabolic and cardiovascular outcomes in patients with type 2 diabetes mellitus

In the published Phase I dose-escalation study in healthy adults, CJC-1295 with DAC showed good tolerability, with injection-site reactions reported as the most common adverse effect

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