10.1161/CIRCULATIONAHA.116.021311 30 MaJ.JiL.LiZ.LiuH.ZhaoC.XiongH.et al (2019)
PMID: 100 Godoy-OrtizASanchez-MuozAParradoMRClvarezMRibellesNDominguezARet al
Based on the formal definition, a focal lesion refers to one specific area, or focus, whereas multifocal refers to more than one focus (foci)
A method for preventing drug-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, a TRPV modulator, a MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of therapy with the drug, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration
New York, Academic Press Pettegrew J, Klunk W, Panchalingam K, Kanfer JN, McClure RJ