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Alternatively, oxidation and activation of GCL may not require additional molecular systems, but may occur by direct interaction with glutathione to mediate redox changes that modulate activity

High concentrations of vitamin C are also maintained in nerve cells, namely in the brain, and the effect of vitamin C on the functioning of the nervous system, including a positive effect on IQ in school children, has been proven

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However, long-term pramlintide treatment is limited by low bioavailability and the short half-life of the drug, which makes it less suitable for chronic therapy due to the high administration frequency (two to three times daily) and therefore high compliance-related demands