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244,245 DJ-1 also binds to the DNA-binding domain of p53, diminishing the DNA-binding affinity of p53 and inhibiting the expression of p53 target genes in a manner that relies on the oxidation of cysteine 106

Upon release, Nrf2 translocates to the nucleus and binds to the antioxidant response element (ARE) located in the promoter of genes coding for antioxidant/detoxifying enzymes and scavengers