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This variability highlights why baseline assessment and close monitoring are medically essential before starting treatment

This circadian rhythm is regulated by food intake, and specifically, secretion and biological action of gut derived peptide hormones, including glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 (GLP-2)

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121 Mutations in the progranulin gene, GRN , which cause a genetic familial FTD, downregulate expression of EAAT2 astrocyte glutamate transporter, which mediates synaptic degeneration