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The recent position statement by the ADA advocating the use of both SGLT2i and GLP-1 RAs is encouraging, indicating that CKD in T2DM is under the spotlight

However, most in vitro studies have identified MSU crystals as inflammasome activators needed to use lipopolysaccharide (LPS) or phorbol-12-myristate-13-acetate (PMA) to trigger the activation of the inflammasome in cells ( Further exploration revealed that during the course of inflammation, FA-related metabolic disorders promote inflammation by affecting the metabolism and microenvironment of macrophages and neutrophils ( 2 Comprehensive overview of fatty acids FAs are organic acids that are defined mainly by the length and saturation of their aliphatic side chain

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10.1210/jc.79.6.1723 J