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A 2025 retrospective cohort study of 210 T2DM patients on oral semaglutide for 18 months found no significant association between rs6923761 or rs761387 genotypes and changes in HbA1c or BMI in that relatively well-controlled population (Candido et al., 2025) suggesting that receptor-level genotype effects may be detectable primarily in subpopulations with higher pharmacological demand or larger baseline disease severity, rather than as universal predictors
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On average, the treated individuals gained an average of 4.6 pounds of lean body mass, and they shed a similar amount of body fat. In other words, they were well on their way to the Liver King physique
However, when combined with sulphonylureas or insulin, the risk increases significantly, and doses of these medications may need reduction under clinical supervision to prevent low blood glucose and associated dizziness
Planning ahead prevents missed doses during travel
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