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pH profiles indicative of rate-limiting nucleophilic displacement in thioltransferase catalysis

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While three forms of cystinosis have been described, the disorder displays a continuum of clinical severity inversely related to the amount of residual cystine-transporting activity

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Keywords: GST, polymorphism, resistance, MAP kinase pathway GSTs As Phase II Detoxification Enzymes Glutathione S-transferases (GSTs) are a family of Phase II detoxification enzymes that function to protect cellular macromolecules from attack by reactive electrophiles