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In mammals, carnitine acts through the reversible esterification of its 3-hydroxyl group by fatty acyl-CoA esters with subsequent translocation of the acylcarnitines produced from one cellular compartment to another

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doi: 10.1089/jmf.2011.0145 81 AminiAMasoumi-MoghaddamSEhtedaAMorrisDL

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Thus, it will be important (i) to insure efficient delivery of the ligands and strong immune activation locally, and (ii) to test these therapies in combination with direct antiviral agents on the market or in development in order to release the HBV-pressure on innate immune cells before inducing inflammatory responses