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Conversely, pathways enriched with downregulated DEGs encompassed PI3K-Akt signaling, calcium signaling, cytokine-cytokine receptor interaction, cell adhesion molecules, focal adhesion, phagosome, ECM-receptor interaction, cholinergic synapse, hematopoietic cell lineage, and malaria (Fig

The principal task at this time is to determine the risk of hepatocellular injury, and this involves two considerations: the time elapsed from the toxic ingestion, and the plasma level of acetaminophen