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Participants were started on lower doses typically 1 mg or 2 mg subcutaneously once weekly and gradually titrated upward over multiple weeks to maintenance doses of 4 mg, 8 mg, or 12 mg administered subcutaneously once weekly

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Emerging imaging studies suggest tirzepatide may improve muscle quality , reducing fat infiltration within muscle tissue even as overall lean mass decreasesindicating a potential improvement in muscle composition rather than functional loss

These practical considerations often prove decisive in real-world decision making