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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers (24, 25)

20 Similarly, Filardo and colleagues found that MACI treatment in osteoarthritic knees had a failure rate of 27.3% at 9-year follow-up

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The most common reactions include transient digestive upset (nausea, vomiting, stomach cramps, or diarrhea), a mild fishy body odor, headache, or soreness and redness where the injection is given

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