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For this reason, people who develop peripheral neuropathy, ataxia, or retinitis pigmentosa (RP) of unknown causes should be screened for vitamin E deficiency (24)

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Observational studies also found that new onset of chronic mild-to-moderate hyperkalemia (K=5.0 to 6.0 mmol/L) was associated with an increased risk of end-stage kidney disease by 30% [18,19]

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Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]