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In histology, all kidney tissues from the mice treated with colistin showed elevated expression of the AKI markers Ngal and Kim-1, tubule dilation, loss of the brush border membranes in the proximal tubules, and the formation of protein casts throughout the kidney tissue, indicating vast tubular damage (Fig

Ammonia detoxification represents a unique benefit of l-citrulline through its participation in the urea cycle

-Promotes energy production and metabolism