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The Wnt and Notch signaling pathways are essential for preserving the quiescent-proliferative equilibrium of intestinal epithelial stem cells 29,30

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As early as the late 1980s, Newsholme and colleagues proposed that the central neurotransmitter 5-HT may serve as a key mediator of central fatigue (Newsholme and Blomstrand, 1995)

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Myssina et al., 2003)

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NRF2-mediated regulation of ferroptosis NRF2, encoded by the NFE2L2 gene, is precisely regulated by the E3-ubiquitin ligase system [83,84,85]

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When combined with a balanced diet and regular exercise, it may enhance fat loss while supporting lean muscle maintenance

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