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As previously reported, the reduction of inflammation may be related to weight loss, that was significant in the different outcome trials, going from a 0.6-kg reduction at 12 weeks with Lixisenatide in ELIXA trial to 4.3 kg at 2 years with injectable semaglutide in SUSTAIN-6 trial [25, 26]

A study using in situ hybridization and polymerase chain reaction techniques did not detect GIP expression in the brain of adult male Sprague-Dawley rats (41)

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